解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The polar nature of the C═O bond commonly allows it to undergo direct attack by nucleophiles at the electrophilic carbon atom in which ketones and aldehydes act as alkyl carbocation equivalents. In contrast, transformations in which ketones and aldehydes act as alkyl radical equivalents (generated in carbonyl carbon) ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax9955
更新日期:2019-10-11 00:00:00
abstract::Retreat from some areas will become unavoidable under intensifying climate change. Existing deployments of managed retreat are at small scale compared to potential future needs, leaving open questions about where, when, and how retreat under climate change will occur. Here, we analyze more than 40,000 voluntary buyout...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax8995
更新日期:2019-10-09 00:00:00
abstract::Posthemorrhagic hydrocephalus (PHH) in premature infants is a common neurological disorder treated with invasive neurosurgical interventions. Patients with PHH lack effective therapeutic interventions and suffer chronic comorbidities. Here, we report a murine lysophosphatidic acid (LPA)-induced postnatal PHH model tha...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax2011
更新日期:2019-10-09 00:00:00
abstract::Dynamic modulation of soft helix in terms of the molecular organization, handedness, and pitch length could result in a sophisticated control over its functions, opening numerous possibilities toward the exploration of previously unidentified applications. Here, we report a dynamic and reversible transformation of a s...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax9501
更新日期:2019-10-04 00:00:00
abstract::The retinoic acid-inducible gene I (RIG-I) innate immune receptor is an important immunotherapeutic target, but we lack approaches for monitoring the physical basis for its activation in vitro. This gap in our understanding has led to confusion about mechanisms of RIG-I activation and difficulty discovering agonists a...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax3641
更新日期:2019-10-02 00:00:00
abstract::Telomerase is a ribonucleoprotein complex that catalyzes addition of telomeric DNA repeats to maintain telomeres in replicating cells. Here, we demonstrate that the telomerase protein hTERT performs an additional role at telomeres that is independent of telomerase catalytic activity yet essential for telomere integrit...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav4409
更新日期:2019-10-02 00:00:00
abstract::Materials with a stochastic microstructure, like foams, typically exhibit low mechanical stiffness, whereas lattices with a designed microarchitecture often show notably improved stiffness. These periodic architected materials have previously been designed by rule, using the Maxwell criterion to ensure that their defo...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw1937
更新日期:2019-09-27 00:00:00
abstract::The design of single-molecule photoswitchable emitters was the first milestone toward the advent of single-molecule localization microscopy, setting a new paradigm in the field of optical imaging. Several photoswitchable emitters have been developed, but they all fluoresce in the visible or far-red ranges, missing the...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax1166
更新日期:2019-09-27 00:00:00
abstract::RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as a promising therapeutic method to treat cancer. In the present study, we showed that natural halloysite nanotube (HNT)-assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacti...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw6499
更新日期:2019-09-25 00:00:00
abstract::Carbon taxes are widely regarded as a potentially effective and economically efficient policy instrument for decarbonizing the global energy supply and thus limiting global warming. The main obstacle is political feasibility because of opposition from citizens and industry. Earmarking revenues from carbon taxation for...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax3323
更新日期:2019-09-18 00:00:00
abstract::Hedgehog signaling is central in embryonic development and tissue regeneration. Disruption of the pathway is linked to genetic diseases and cancer. Binding of the secreted ligand, Sonic hedgehog (ShhN) to its receptor Patched (PTCH1) activates the signaling pathway. Here, we describe a 3.4-Å cryo-EM structure of the h...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw6490
更新日期:2019-09-18 00:00:00
abstract::Local thermal magnetization fluctuations in Li-doped MnTe are found to increase its thermopower α strongly at temperatures up to 900 K. Below the Néel temperature (TN ~ 307 K), MnTe is antiferromagnetic, and magnon drag contributes αmd to the thermopower, which scales as ~T3. Magnon drag persists into the paramagnetic...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat9461
更新日期:2019-09-13 00:00:00
abstract::Kozmin et al. contend that observations previously reported regarding the antimicrobial and antitumor activities of 6-N-hydroxy aminopurine (6-HAP) were incorrect. Their conclusions rely on poorly characterized reagents and focus strictly on in vitro techniques without validation in relevant mammalian model systems. W...
journal_title:Science advances
pub_type: 评论,杂志文章
doi:10.1126/sciadv.aay5611
更新日期:2019-09-11 00:00:00
abstract::Dust condensation and coagulation in the early solar system are the first steps toward forming the terrestrial planets, but the time scales of these processes remain poorly constrained. Through isotopic analysis of small Ca-Al-rich inclusions (CAIs) (30 to 100 μm in size) found in one of the most pristine chondrites, ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw3350
更新日期:2019-09-11 00:00:00
abstract::The miraculously preserved 2000-year-old Dead Sea Scrolls, ancient texts of invaluable historical significance, were discovered in the mid-20th century in the caves of the Judean desert. The texts were mainly written on parchment and exhibit vast diversity in their states of preservation. One particular scroll, the 8-...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw7494
更新日期:2019-09-06 00:00:00
abstract::A withdrawal-associated impairment in β-endorphin neurotransmission in the arcuate nucleus (ARC) of the hypothalamus is associated with alcohol dependence characterized by a chronic relapsing disorder. Although acupuncture activates β-endorphin neurons in the ARC projecting to the nucleus accumbens (NAc), a role for A...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax1342
更新日期:2019-09-04 00:00:00
abstract::Pressure is a key parameter in the physics and chemistry of planet formation and evolution. Previous studies have erroneously assumed that internal pressures monotonically increase with the mass of a body. Using smoothed particle hydrodynamics and potential field method calculations, we demonstrate that the hot, rapid...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav3746
更新日期:2019-09-04 00:00:00
abstract::The human gut microbiota established during infancy has persistent effects on health. In vitro studies have suggested that human milk oligosaccharides (HMOs) in breast milk promote the formation of a bifidobacteria-rich microbiota in infant guts; however, the underlying molecular mechanism remains elusive. Here, we ch...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw7696
更新日期:2019-08-28 00:00:00
abstract::Adenosine and its receptors play a key role in bone homeostasis and regeneration. Extracellular adenosine is generated from CD39 and CD73 activity in the cell membrane, through conversion of adenosine triphosphate to adenosine monophosphate (AMP) and AMP to adenosine, respectively. Despite the relevance of CD39/CD73 t...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax1387
更新日期:2019-08-21 00:00:00
abstract::The impact of the FMR1 premutation on human health is the subject of considerable controversy. A fundamental unanswered question is whether carrying the premutation allele is directly correlated with clinical phenotypes. A challenging problem in past genotype-phenotype studies of the FMR1 premutation is ascertainment ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw7195
更新日期:2019-08-21 00:00:00
abstract::Charge order is universal among high-Tc cuprates, but its relation to superconductivity is unclear. While static order competes with superconductivity, dynamic order may be favorable and even contribute to Cooper pairing. Using time-resolved resonant soft x-ray scattering at a free-electron laser, we show that the cha...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax3346
更新日期:2019-08-16 00:00:00
abstract::Organic-inorganic hybrid halide perovskites are emerging as promising materials for next-generation light-emitting diodes (LEDs). However, the poor stability of these materials has been the main obstacle challenging their application. Here, we performed first-principles calculations, revealing that the molecule dissoc...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw8072
更新日期:2019-08-16 00:00:00
abstract::Proinflammatory activation and accumulation of adipose tissue macrophages (ATMs) are associated with increased risk of insulin resistance in obesity. Here, we described the previously unidentified role of selenocysteine insertion sequence-binding protein 2 (SBP2) in maintaining insulin sensitivity in obesity. SBP2 was...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav0198
更新日期:2019-08-14 00:00:00
abstract::Intrachain charge transport is unique to conjugated polymers distinct from inorganic and small molecular semiconductors and is key to achieving high-performance organic electronics. Polymer backbone planarity and thin film morphology sensitively modulate intrachain charge transport. However, simple, generic nonsynthet...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw7757
更新日期:2019-08-09 00:00:00
abstract::Regulatory T (Treg) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the Treg cell program. We found that mice deficient in Bcl11b TF solely in Treg cells developed fatal autoimmunity, and Bcl11b-deficient...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0480
更新日期:2019-08-07 00:00:00
abstract::Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect of HA nanoparticles (n-HA) against various cancer cells was reported. This study was aimed at assessing the translational value of n-HA both as a bone-regenerating material ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax6946
更新日期:2019-08-02 00:00:00
abstract::Earthquakes in the continental crust commonly occur in the upper 15 to 20 km. Recent studies demonstrate that earthquakes also occur in the lower crust of collision zones and play a key role in metamorphic processes that modify its physical properties. However, details of the failure process and sequence of events tha...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0913
更新日期:2019-07-31 00:00:00
abstract::Solar-thermal desalination (STD) is a potentially low-cost, sustainable approach for providing high-quality fresh water in the absence of water and energy infrastructures. Despite recent efforts to advance STD by improving heat-absorbing materials and system designs, the best strategies for maximizing STD performance ...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aax0763
更新日期:2019-07-26 00:00:00
abstract::A growing body of empirical evidence is revealing the value of nature experience for mental health. With rapid urbanization and declines in human contact with nature globally, crucial decisions must be made about how to preserve and enhance opportunities for nature experience. Here, we first provide points of consensu...
journal_title:Science advances
pub_type: 杂志文章,评审
doi:10.1126/sciadv.aax0903
更新日期:2019-07-24 00:00:00
abstract::A sulfide-oxidizing microorganism, Desulfurivibrio alkaliphilus (DA), generates a consistent enrichment of sulfur-34 (34S) in the produced sulfate of +12.5 per mil or greater. This observation challenges the general consensus that the microbial oxidation of sulfide does not result in large 34S enrichments and suggests...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw1480
更新日期:2019-07-24 00:00:00
abstract::Understanding the remarkable excitonic effects and controlling the exciton binding energies in two-dimensional (2D) semiconductors are crucial in unlocking their full potential for use in future photonic and optoelectronic devices. Here, we demonstrate large excitonic effects and gate-tunable exciton binding energies ...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw2347
更新日期:2019-07-19 00:00:00
abstract::B cell activation is regulated by the stimulatory or inhibitory co-receptors of B cell receptors (BCRs). Here, we investigated the signaling mechanism of Fc receptor-like 1 (FcRL1), a newly identified BCR co-receptor. FcRL1 was passively recruited into B cell immunological synapses upon BCR engagement in the absence o...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw0315
更新日期:2019-07-17 00:00:00
abstract::Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by elect...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw4357
更新日期:2019-07-10 00:00:00
abstract::Changes in chromatin organization occur during aging. Overexpression of histones partially alleviates these changes and promotes longevity. We report that deletion of the histone H3-H4 minor locus HHT1-HHF1 extended the replicative life span of Saccharomyces cerevisiae. This longevity effect was mediated through TOR s...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav1165
更新日期:2019-07-10 00:00:00
abstract::A semiconductor nanowire with strong spin-orbit coupling in proximity to a superconductor is predicted to display Majorana edge states emerging under a properly oriented magnetic field. The experimental investigation of these exotic states requires assessing the one-dimensional (1D) character of the nanowire and under...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav1235
更新日期:2019-07-05 00:00:00
abstract::Mineralization is the most fundamental process in vertebrates. It is predominantly mediated by osteoblasts, which secrete mineral precursors, most likely through matrix vesicles (MVs). These vesicular structures are calcium and phosphate rich and contain organic material such as acidic proteins. However, it remains la...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aax0672
更新日期:2019-07-03 00:00:00
abstract::Large-scale modes of climate variability can force widespread crop yield anomalies and are therefore often presented as a risk to food security. We quantify how modes of climate variability contribute to crop production variance. We find that the El Niño Southern Oscillation (ENSO), the Indian Ocean Dipole (IOD), trop...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw1976
更新日期:2019-07-03 00:00:00
abstract::Controlling the polarization state and the propagation direction of photons is a fundamental prerequisite for many nanophotonic devices and a precursor for future on-chip communication, where the emission properties of individual emitters are particularly relevant. Here, we report on the emission of partially circular...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aav7588
更新日期:2019-06-28 00:00:00
abstract::E2F is a family of master transcription regulators involved in mediating diverse cell fates. Here, we show that residue-specific arginine methylation (meR) by PRMT5 enables E2F1 to regulate many genes at the level of alternative RNA splicing, rather than through its classical transcription-based mechanism. The p100/TS...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aaw4640
更新日期:2019-06-26 00:00:00
abstract::Fluctuations in biodiversity, large and small, pervade the fossil record, yet we do not understand the processes generating them. Here, we extend theory from nonequilibrium statistical physics to describe the fat-tailed form of fluctuations in Phanerozoic marine invertebrate richness. Using this theory, known as super...
journal_title:Science advances
pub_type: 杂志文章
doi:10.1126/sciadv.aat0122
更新日期:2019-06-26 00:00:00